Trema orientalis inhibits butylcholinesterase and lipid peroxidation in rat brain, in vitro

Jamiyu A. Saliu

Abstract



Objectives: Traditionally and recently, numerous plants have been used to treat cognitive disorders, inc
luding neurodegenerative diseases and different neuropharmacological disorders. The paradigm shift from conventional drugs to the use of herbal and medicinal plants are on increase due to side effects and cost of the drugs especially in developing countries. Trema orientalis traditionally used in treating various disorders including, diseases of the brain, pain in the chest and joints was the focus of this study. The study was aimed at evaluating the effects of the aqueous extract of Trema orientalis leaf on enzyme associated with neurodegenerative disease.
Methods: The extract was prepared by standard soxhlet extraction procedure. Anumber of biochemical parameters that were determined include total phenol, total flavonoid, reducing power (FRAP), ABTS* scavenging ability, Fe2+ chelating ability, DPPH* scavenging ability, butyrylcholinesterase (BChE) inhibition and lipid peroxidation assays.
Results: The results revealed that the aqueous extract of Trema orientalis leaf has potent reducing power (FRAP), ABTS* scavenging ability, Fe2+ chelating ability, DPPH* scavenging abilities in a concentration-dependent fashion.
It also exhibited inhibitory actions on butyrylcholinesterase (BChE) and lipid peroxidation of rat's brain in a dose- dependent manner.
Conclusion: This experimental work has shown that Trema orientalis is a good source of aqueous extractable phytochemicals with strong antioxidant activities, inhibitory activity against key enzyme associated with neurodegeneration. It could therefore be suggested as a potential candidate in the management of neurodegenerative diseases.

Keywords


Trema orientalis, neurodegenerative, butyrylcholinesterase, brain, antioxidant, enzyme.

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